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當前位置: 首頁 » 食品資訊 » 外訊導讀 » 歐盟評估非轉基因塔賓曲霉菌株GOX生產的葡糖氧化酶的安全性

歐盟評估非轉基因塔賓曲霉菌株GOX生產的葡糖氧化酶的安全性

放大字體  縮小字體 時間:2025-03-05 10:54 來源:食品伙伴網 作者: 澤夕   
核心提示:2025年3月4日,歐盟食品安全局就一種食品酶葡糖氧化酶(glucose oxidase)的安全性評價發(fā)布意見。
   食品伙伴網訊  2025年3月4日,歐盟食品安全局就一種食品酶葡糖氧化酶(glucose oxidase)的安全性評價發(fā)布意見。
  
  據了解,這種食品酶是由非轉基因塔賓曲霉菌株GOX生產的,旨在用于四種食品生產過程。
  
  經過評估,專家小組認為,在預期的使用條件下,不能排除飲食暴露引起過敏反應的風險,但這種情況發(fā)生的可能性很低。根據所提供的數據,評估小組得出結論,這種食品酶在預期使用條件下不會引起安全問題。部分原文報道如下:
  
  The food enzyme glucose oxidase (β-d-glucose: oxygen 1-oxidoreductase, i.e. EC 1.1.3.4) is produced with the non-genetically modified Aspergillus tubingensis strain GOX by DSM Food Specialties. The food enzyme was free from viable cells of the production organism. It is intended to be used in four food manufacturing processes. Dietary exposure to the food enzyme-total organic solids (TOS) was estimated to be up to 1.555 mg TOS/kg body weight (bw) per day in European populations. Genotoxicity tests did not indicate a safety concern. The systemic toxicity was assessed by means of a repeated dose 90-day oral toxicity study in rats. The Panel identified a no observed adverse effect level of 2000 mg TOS/kg bw per day, the highest dose tested, which when compared with the estimated dietary exposure, resulted in a margin of exposure of at least 1286. A search for the homology of the amino acid sequence of the glucose oxidase to known allergens was made, and one match with a contact allergen was found. The Panel considered that a risk of allergic reactions upon dietary exposure to the food enzyme cannot be excluded, but the likelihood is low. based on the data provided, the Panel concluded that this food enzyme does not give rise to safety concerns under the intended conditions of use.
  
  本文由食品伙伴網食品資訊中心編輯,有任何疑問,請聯系news@foodmate.net。
日期:2025-03-05
 
 
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